Someone has probably said this before, but if you think about it, every single event in the show after the pilots is all Misako's fault.

If Misako didn't drop off Lloyd at Darkley's, The serpentine would stay locked away, the great devourer would never be freed, Wu wouldn't free Garmadon with the traveler's tea, Garmadon would never find the Overlord, The Final battle wouldn't happen, Rebooted Wouldn't happen, since Zane didn't die all of Tournament of Elements wouldn't happen, as a result, Morro wouldn't be freed and since Clouse remained mortal, Nadakhan would stay in the teapot, Cole would never become a Ghost, etc. ...